Endocrine Abstracts

Postmenopausal osteoporosis is a chronic condition requiring long-term treatment. Based on personalized patient care the physician should decide the optimal treatment strategy, namely the use of the available osteoanabolic and antiresorptive agents, sequentially or even in combination, in the most effective and safe way. Transitioning from one antiresorptive to another is probably the most common treatment sequence in clinical practice. In this context transition to a potent o...

Introduction: Low bone density is a frequent finding in both women and men of older age. There is not enough data about bone density in younger adults and especially men. In this study we measured bone density in healthy males per decade of age.Method: We measured bone density (BMD), T-score, Z-score and body mass index (BMI) in 1902 healthy men, age 20–59 years old. The study population was divided into four groups according to th...

Objective: Human immunodeficiency virus (HIV)-infected patients demonstrate an increased risk of osteoporosis and fractures. The pathophysiology of HIV-induced bone loss is complex and remains largely unknown. Recent studies have identified a molecular signature of small non-coding RNAs (microRNAS) in patients with osteoporosis, but data are lacking in HIV-infected patients. The aim of the present study was to investigate the expression profile of microRNAs related to bone met...

Background: Epigenetic changes appear to be implicated in the development of parathyroid tumors. In this study we investigated the microRNA expression profile in the serum and tissue samples from patients with primary hyperparathyroidism (PHP) due to sporadic parathyroid adenomas (SPAs).Methods: Our study cohort consisted of 40 patients with PHP due to SPAs that underwent parathyroidectomy (PTX).MicroRNA extraction was performed fr...

Background: The normal cut-offs of screening and diagnostic tests for autonomous aldosterone (AAS) and cortisol (ACS) secretion are poorly defined, mainly due to the presence of adrenal adenomas among those who have served as controls and the stimulating effect of ACTH on aldosterone secretion.Methods: We investigated cortisol and aldosterone secretion in 151 patients with benign cortical adrenal adenomas (BCAA) and in 119 healthy controls with a normal ...